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Tylosin production in the culture of Streptomyces fradiae T1558 was improved by decreasing the apparent viscosity by means of a newly designed medium. When a medium containing 15 g/l Pharmamedia (a proprietary nutrient derived from cotton seed) and 25 g/l gluten meal was used in a 3-l air-lift bioreactor, the tylosin concentration and apparent viscosity of the broth were 2.1 g/l and 190 cP, on day...
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