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Hepatocellular carcinoma (HCC) is one of the most fatal malignancies with few effective treatment options all around the world. The efficacy of the arisen immune checkpoint therapy is still uncertain due to local immunosuppression. In order to further overcome T cell suppression in the tumor immune microenvironment while promoting the immune response of antigen‐presenting cells, a biointerfacing antagonizing...
Biointerfacing Nanoparticles
In article number 2105237, Dong‐Sheng Huang, Tian Yang, and co‐workers develop a strategy of targeting therapeutic nanoparticles effectively reversing the immune‐inhibiting microenvironment for enhanced PD‐L1 checkpoint combination therapy. The platelet membrane cloaked nanoparticles activate the CD8+ T lymphocytes and antigen presentation of dendritic cells as well as...
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