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Aptamers face challenges for use outside the ideal conditions in which they are developed. These difficulties are most palpable in vivo due to nuclease activities, rapid clearance, and off‐target binding. Herein, we demonstrate that a polyphosphodiester‐backboned molecular brush can suppress enzymatic digestion, reduce non‐specific cell uptake, enable long blood circulation, and rescue the bioactivity...
Aptamers face challenges for use outside the ideal conditions in which they are developed. These difficulties are most palpable in vivo due to nuclease activities, rapid clearance, and off‐target binding. Herein, we demonstrate that a polyphosphodiester‐backboned molecular brush can suppress enzymatic digestion, reduce non‐specific cell uptake, enable long blood circulation, and rescue the bioactivity...
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