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Determination of the structures of fibroblast growth factors and interleukin-1s has previously revealed that they both adopt a β-trefoil fold, similar to those found in Kunitz soybean trypsin inhibitors, ricin-like toxins, plant agglutinins and hisactophilin. These families possess distinct functions and occur in different subcellular localisations, and they appear to lack significant similarities...
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