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We performed positron emission tomography (PET) using 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) to evaluate the pharmacokinetics of nasal drug absorption in the rat. The dosing solution of [18F]FDG was varied in volume (ranging from 5 to 25μl) and viscosity (using 0% to 3% concentrations of hydroxypropylcellulose). We modeled the pharmacokinetic parameters regarding the nasal cavity and pharynx using...
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