Search results for: Ruyi Zhang

Items from 1 to 20 out of 30 results

article

Estimating the key outcomes and hepatocellular carcinoma risk in patients in immune‐tolerant phase of chronic hepatitis B virus infection: A systematic review and meta‐analysis

Min Liu, Taixue Zhao, Jinyang Zhang, Bing Bu, more

Reviews in Medical Virology > 34 > 4 > n/a - n/a

The question of whether patients in the immune‐tolerant (IT) phase of chronic hepatitis B virus (HBV) infection should undergo antiviral therapy and determine the optimal regimen remains unclear. A comprehensive search of PubMed, Embase, MEDLINE, Cochrane Library, and Wanfang Data from inception to 5 December 2023, was conducted. Studies reporting on key outcomes such as HBV DNA undetectability, HBeAg...

article

AhR may be involved in Th17 cell differentiation in chronic hepatitis B

Ruyi Zhang, Huaie Liu, Jie Lin, Jie Ding, more

Journal of Viral Hepatitis > 30 > 12 > 939 - 950

Th17 cells which are crucial for host immunity have been demonstrated to increase HBV infection. However, the mechanism of the Th17 cell increase is unknown. Hence, the mechanism of Th17 cell enhancement is important to provide a theoretical foundation for chronic hepatitis B immunotherapy. This study included 15 instances in the healthy control (HC) and 15 cohorts in the chronic hepatitis B (CHB)...

article

Isoconversional models toward the curing kinetics of self‐healable epoxy resin TGDDM and acid anhydride

Zhihang Ma, Xiao Wang, Junru Li, Xinlin Li, more

Journal of Applied Polymer Science > 139 > 31 > n/a - n/a

The reaction process and curing mechanism of self‐healable epoxy resin TGDDM and curing agent TA are complicated. In this paper, the curing reaction kinetic mechanism of the system is studied from the perspective of isoconversional models. The nth‐order model and autocatalysis model are established for observations of heat flow versus temperature and time during real‐time curing obtained by non‐isothermal...

article

The biological process of lysine‐tRNA charging is therapeutically targetable in liver cancer

Ruyi Zhang, Lisanne Noordam, Xumin Ou, Buyun Ma, more

Liver International > 41 > 1 > 206 - 219

Background & Aims Mature transfer RNAs (tRNA) charged with amino acids decode mRNA to synthesize proteins. Dysregulation of translational machineries has a fundamental impact on cancer biology. This study aims to map the tRNAome landscape in liver cancer patients and to explore potential therapeutic targets at the interface of charging amino acid with tRNA. Methods Resected tumour and paired...

article

A simplified qPCR method revealing tRNAome remodeling upon infection by genotype 3 hepatitis E virus

Xumin Ou, Buyun Ma, Ruyi Zhang, Zhijiang Miao, more

FEBS Letters > 594 > 12 > 2005 - 2015

The landscape of tRNA–viral codons regulates viral adaption at the translational level, presumably through adapting to host codon usage or modulating the host tRNAome. We found that the major zoonotic genotype of hepatitis E virus (HEV) has not adapted to host codon usage, prompting exploration of the effects of HEV infection on the host tRNAome. However, tRNAome quantification is largely impeded...

article

Reversibly immortalized human umbilical cord–derived mesenchymal stem cells (UC‐MSCs) are responsive to BMP9‐induced osteogenic and adipogenic differentiation

Yi Shu, Chao Yang, Xiaojuan Ji, Linghuan Zhang, more

Journal of Cellular Biochemistry > 119 > 11 > 8872 - 8886

Human mesenchymal stem cells (MSCs) are a heterogeneous subset of nonhematopoietic multipotent stromal stem cells and can differentiate into mesodermal lineage, such as adipocytes, osteocytes, and chondrocytes, as well as ectodermal and endodermal lineages. Human umbilical cord (UC) is one of the most promising sources of MSCs. However, the molecular and cellular characteristics of UC‐derived MSCs...

article

Radix Scutellariae Attenuates CUMS-Induced Depressive-Like Behavior by Promoting Neurogenesis via cAMP/PKA Pathway

Ruyi Zhang, Liting Guo, Zhouye Ji, Xiaoxi Li, more

Neurochemical Research > 2018 > 43 > 11 > 2111-2120

Chronic mild unpredictable stress (CUMS) causes neurogenesis damage in the hippocampus and depressive-like behaviors such as cognitive impairment. Radix Scutellariae from the dry root of Scutellaria baicalensis Georgi, with the common name Baikal skullcap. In this study, we demonstrated that Radix Scutellariae (RS 500, 1000 mg/kg) notably improved the behavior of the rat, such as shortened escape...

article

Bioactive hydrolysates from casein: generation, identification, and in silico toxicity and allergenicity prediction of peptides

Maolin Tu, Hanxiong Liu, Ruyi Zhang, Hui Chen, more

Journal of the Science of Food and Agriculture > 98 > 9 > 3416 - 3426

BACKGROUND Bioactive casein peptides have attracted considerable attention for their applications in industry. However, there is little clarity regarding mass spectrometric profiles for peptides in enzymatic hydrolysates of casein produced under varying conditions. In this study, the compositions of the peptides from casein hydrolysates were compared for different enzyme/substrate ratio (E/S) and...

article

Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes (imPODs)

Xinyi Yu, Liqun Chen, Ke Wu, Shujuan Yan, more

Genes & Diseases > 2018 > 5 > 2 > 137-149

Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney. Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases, which requires a thorough understanding of podocyte cell biology. As mature podocytes lose proliferative...

article

Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference

Shujuan Yan, Ruyi Zhang, Ke Wu, Jing Cui, more

Genes & Diseases > 2018 > 5 > 2 > 172-184

Mesenchymal stem cells (MSCs) are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic, chondrogenic and adipogenic lineages. We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood...

article

Flexible Electronics: Mechanical Strain‐Tunable Microwave Magnetism in Flexible CuFe₂O₄ Epitaxial Thin Film for Wearable Sensors (Adv. Funct. Mater. 10/2018)

Wenlong Liu, Ming Liu, Rong Ma, Ruyi Zhang, more

Advanced Functional Materials > 28 > 10 > n/a - n/a

A large tunable and superiorly stable microwave magnetism in flexible CuFe₂O₄ epitaxial thin films achieved through purely mechanical strains and deformations is reported by Ming Liu, Hong Wang, and co‐workers in article number 1705928. Purely machinery‐tunable microwave magnetism devices that are lightweight, flexible, and wearable are promising for the application in flexible passive sensing systems...

article

Mechanical Strain‐Tunable Microwave Magnetism in Flexible CuFe₂O₄ Epitaxial Thin Film for Wearable Sensors

Wenlong Liu, Ming Liu, Rong Ma, Ruyi Zhang, more

Advanced Functional Materials > 28 > 10 > n/a - n/a

Purely mechanical strain‐tunable microwave magnetism device with lightweight, flexible, and wearable is crucial for passive sensing systems and spintronic devices (noncontact), such as flexible microwave detectors, flexible microwave signal processing devices, and wearable mechanics‐magnetic sensors. Here, a flexible microwave magnetic CuFe₂O₄ (CuFO) epitaxial thin film with tunable ferromagnetic...

article

The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs

Zongyue Zeng, Bo Huang, Shifeng Huang, Ruyi Zhang, more

Genes & Diseases > 2018 > 5 > 1 > 62-74

While the human genome is pervasively transcribed, <2% of the human genome is transcribed into protein-coding mRNAs, leaving most of the transcripts as noncoding RNAs, such as microRNAs and long-noncoding RNAs (lncRNAs), which are critical components of epigenetic regulation. lncRNAs are emerging as critical regulators of gene expression and genomic stability. However, it remains largely unknown...

article

Dexmedetomidine mitigate acute lung injury by inhibiting IL-17-induced inflammatory reaction

Yong Zhang, Shushan Jia, Tianqin Gao, Ruyi Zhang, more

Immunobiology > 2018 > 223 > 1 > 32-37

Interleukin-17 (IL-17) is considered to play an important role in the pathogenesis of a number of inflammatory conditions. Previous studies demonstrated that intranasal injections of IL-17 resulted in pulmonary inflammation and lung damage, we therefore hypothesize that dexmedetomidine, a potent α2 adrenergic receptor agonist that shows anti-inflammation effects in several animal models of inflammation,...

article

Highly conductive n-type NiCo2O4-δ epitaxial thin films grown by RF sputtering

Ruyi Zhang, Ming Liu, Wenlong Liu, Hong Wang

Materials Letters > 2017 > 199 > C > 164-167

NiCo₂O_4-δ (NCO) epitaxial thin films have been grown on MgAl₂O₄(001) substrates at different Ar/O₂(1:1) pressure by RF sputtering technique. HRXRD study indicates best crystalline quality and smallest unit cell volume are obtained in NCO thin films deposited at 75Pa. Hall measurement reveals NCO thin films are of n-type conductivity with the electron mobility and electron density of NCO films in the...

article

Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine

Cody S. Lee, Elliot S. Bishop, Ruyi Zhang, Xinyi Yu, more

Genes & Diseases > 2017 > 4 > 2 > 43-63

With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology, it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies. Despite numerous setbacks, efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human...

article

Sensitive and selective colorimetric detection of glutathione in human plasma with 2,2′–azino–bis(3–ethylbenzothiazoline–6–sulfonic acid) and Ag+ ion

Yinhuan Li, Xiaoying Liu, Ruyi Zhang

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy > 2017 > 173 > C > 880-885

Glutathione is of vital importance to human beings through involving in many cellular functions. Simple and sensitive methods capable of detecting glutathione in biological samples are significant to diagnosis and prevention of disease. Here a simple, label–free, and sensitive colorimetric method was developed for the determination of glutathione. It was observed that Ag⁺ ion could directly oxidize...

article

MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2

Ruyi Zhang, Shujuan Yan, Jing Wang, Fang Deng, more

Tumor Biology > 2016 > 37 > 3 > 3479-3488

Osteosarcoma (OS) is the most common primary malignant bone tumor in young patients. However, treatment paradigms and survival rates have not improved in decades. MicroRNAs have been shown to be critical regulators of physiological homeostasis and pathological process, including bone disease. Nearly half of the microRNA (miRNA) genes are located at genomic regions and fragile sites known to be frequently...

article

Dexmedetomidine attenuates acute lung injury induced by lipopolysaccharide in mouse through inhibition of MAPK pathway

Yingzhen Xu, Ruyi Zhang, Chunli Li, Xue Yin, more

Fundamental & Clinical Pharmacology > 29 > 5 > 462 - 471

Dexmedetomidine (Dex) is widely used for sedation in intensive care units and can be used as an adjunct to anesthetics. Previous studies have demonstrated that Dex has anti‐inflammatory property. In this study, we aim to explore the potential therapeutic effects and mechanisms of Dex on lipopolysaccharide (LPS)‐induced acute lung injury (ALI) in mice. To induce ALI, mice were intraperitoneally injected...

article

BMP9-induced osteogenic differentiation is partially inhibited by miR-30a in the mesenchymal stem cell line C3H10T1/2

Ruyi Zhang, Yaguang Weng, Baolin Li, Yingjiu Jiang, more

Journal of Molecular Histology > 2015 > 46 > 4-5 > 399-407

In the bone morphogenetic protein (BMP) family, BMP9 is the strongest inducer of osteogenic differentiation in mesenchymal stem cells. Recent studies have suggested that the miR-30 family regulates cell proliferation and osteoblastic differentiation. In the present study, we found that expression of only one miR-30 family member, miR-30a, first decreased and then increased during BMP9-induced osteogenic...

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INFONA - science communication portal

Search results for: Ruyi Zhang

Estimating the key outcomes and hepatocellular carcinoma risk in patients in immune‐tolerant phase of chronic hepatitis B virus infection: A systematic review and meta‐analysis

AhR may be involved in Th17 cell differentiation in chronic hepatitis B

Isoconversional models toward the curing kinetics of self‐healable epoxy resin TGDDM and acid anhydride

The biological process of lysine‐tRNA charging is therapeutically targetable in liver cancer

A simplified qPCR method revealing tRNAome remodeling upon infection by genotype 3 hepatitis E virus

Reversibly immortalized human umbilical cord–derived mesenchymal stem cells (UC‐MSCs) are responsive to BMP9‐induced osteogenic and adipogenic differentiation

Radix Scutellariae Attenuates CUMS-Induced Depressive-Like Behavior by Promoting Neurogenesis via cAMP/PKA Pathway

Bioactive hydrolysates from casein: generation, identification, and in silico toxicity and allergenicity prediction of peptides

Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes (imPODs)

Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference

Flexible Electronics: Mechanical Strain‐Tunable Microwave Magnetism in Flexible CuFe₂O₄ Epitaxial Thin Film for Wearable Sensors (Adv. Funct. Mater. 10/2018)

Mechanical Strain‐Tunable Microwave Magnetism in Flexible CuFe₂O₄ Epitaxial Thin Film for Wearable Sensors

The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs

Dexmedetomidine mitigate acute lung injury by inhibiting IL-17-induced inflammatory reaction

Highly conductive n-type NiCo2O4-δ epitaxial thin films grown by RF sputtering

Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine

Sensitive and selective colorimetric detection of glutathione in human plasma with 2,2′–azino–bis(3–ethylbenzothiazoline–6–sulfonic acid) and Ag+ ion

MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2

Dexmedetomidine attenuates acute lung injury induced by lipopolysaccharide in mouse through inhibition of MAPK pathway

BMP9-induced osteogenic differentiation is partially inhibited by miR-30a in the mesenchymal stem cell line C3H10T1/2

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