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The components of renin-angiotensin system (RAS) are expressed in the kidney and bone. Kidney disease and bone injury are common complications associated with diabetes. This study aimed to investigate the effects of an angiotensin-converting enzyme inhibitor, captopril, on the kidney and bone of db/db mice. The db/db mice were orally administered by gavage with captopril for 8weeks with db/+ mice...
Former studies suggested an adverse effect of hypervitaminosis A on bone health, while the effects of retinol and its precursor (β-carotene) remain uncertain in populations consuming vitamin A (VA) mainly from plant sources.We investigated the association of serum, dietary retinol, and β-carotene with bone mineral density (BMD) in Chinese adults.We recruited 2101 women and 1053 men (aged 40–75years)...
Human chondrocytes and annulus fibrosus cells of intervertebral disc (IVD) express osteoprotegerin (OPG), but the effect of OPG on the pathogenesis of IVD degeneration remains unknown. Here we assessed the phenotype change of IVD in OPG −/− mice.The IVDs from 12-, 20-, and 28-week-old OPG −/− mice and WT controls were subjected to histologic analyses including TRAP staining for osteoclasts,...
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