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ObjectiveThe Alzheimer disease (AD) APOEε4 risk allele associates with an earlier age at onset and increased amyloid‐β deposition, whereas the protective APOEε2 allele delays the onset and appears to prevent amyloid‐β deposition. Yet the clinical and pathological effects of APOEε2 remain uncertain because of its relative rarity. We investigated the effects of APOEε2 and ε4 alleles on AD pathology...
Recently, ∼16% of participants in an anti‐Aβ passive immunotherapy trial for mild‐to‐moderate Alzheimer disease (AD) had a negative baseline amyloid positron emission tomography (PET) scan. Whether they have AD or are AD clinical phenocopies remains unknown. We examined the 2005–2013 National Alzheimer's Coordinating Center autopsy database and found that ∼14% of autopsied subjects clinically diagnosed...
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