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Objectives: After transurethral resection, the local and systemic side effects of Bacillus Calmette-Guerin (BCG) instillations were assessed during a 6-week induction course followed by 3 weekly maintenance instillations at 3, 6, 12, 18, 24, 30 and 36 months to determine if BCG toxicity increases over time.Methods: 487 patients who received BCG in a multicenter phase III trial were included. Side...
Objectives: Previous publications have suggested that patients developing local and/or systemic side effects to Bacillus Calmette-Guerin (BCG) have a better clinical result, however it is necessary to determine if toxicity is responsible for improved efficacy.Methods: After transurethral resection, intravesical instillations of BCG were given during a 6-week induction course followed by 3-weekly maintenance...
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