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Submerged Cells
The formation of a liquid meniscus in submerged cell cultures is common, but its impact on in vitro particle dosimetry has been overlooked. In article number 2206903, through experiments and mathematical modeling, Sandor Balog, Alke Petri‐Fink, and co‐workers identify key factors influencing nanoparticle dose and observe a significant gradient formation between the center and the wall...
Understanding the interaction between cells and nanoparticles (NPs) is vital to understand the hazard associated with nanoparticles. This requires quantifying and interpreting dose‐response relationships. Experiments with cells cultured in vitro and exposed to particle dispersions mainly rely on mathematical models that estimate the received nanoparticle dose. However, models need to consider that...
Nanocomposite materials benefit from the diverse physicochemical properties featured by nanoparticles, and the presence of nanoparticle concentration gradients can lend functions to macroscopic materials beyond the realm of classical nanocomposites. It is shown here that linearity and time‐shift invariance obtained via the synergism of two independent physical phenomena—translational self‐diffusion...
Nanoparticle surface chemistry is a key component for nanoparticle‐cell interactions. Positively charged amines are hypothesized to drive these via Coulombic interactions with a negatively charged cell membrane. In article number 1802088, Calum Kinnear, Thomas L. Moore, Alke Petri‐Fink, and co‐workers report that the degree of amine methylation (i.e. amine bulkiness) is critical in mediating the nanoparticle‐cell...
Amino groups presented on the surface of nanoparticles are well‐known to be a predominant factor in the formation of the protein corona and subsequent cellular uptake. However, the molecular mechanism underpinning this relationship is poorly defined. This study investigates how amine type and density affect the protein corona and cellular association of gold nanoparticles with cells in vitro. Four...
Malaria is caused by Plasmodium sp. parasites transmitted by infected female Anopheles sp. mosquitoes. The survival of the parasites in the host relies on detoxifying free heme by biocrystallization into insoluble crystals called hemozoin. This mechanism of self‐preservation is targeted by a certain class of antimalarial drugs, which are screened and selected based on their capacity to inhibit the...
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