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Background/Aims: The aim of this study was to examine the metabolism of isoursodeoxycholic acid (isoUDCA) in humans.Methods: IsoUDCA was synthesized of > 99% purity and administered orally for 1 week, 3x250 mg/day, to six healthy male subjects. Bile acids were extracted from duodenal bile, serum, and 24-h urine samples collected before and at the end of the study period, separated into groups of...
Background: Rifampin was shown to relieve pruritus in cholestatic liver diseases. There has been much speculation about the origin of pruritus, but it has not yet been comprehensively explained. The role of bile acids in producing pruritus is obscure and still under debate. Since rifampin both inhibits the uptake of bile acids into the hepatocyte and strongly induces mixed-function oxidases in the...
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