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The HS2 enhancer in the β-globin locus control region (LCR) regulates transcription of the globin genes 10–50kb away. Earlier studies show that a transcription mechanism initiated by the HS2 enhancer through the intervening DNA in the direction of the cis-linked promoter and gene mediates long-range enhancer function. Here, we further analyzed the enhancer-initiated RNAs and their mode of transcription...
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