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An in situ study was designed to investigate naturally developed demineralisation in human enamel in a widely non-destructive manner in combination with X-ray microtomography. Samples of human enamel were carried in the oral cavity of participants for 24h daily for either 21 or 29 days using so-called intraoral mandibular appliances (ICTs). Demineralisation was thereby generated in a natural way without...
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