The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
K‐ras (KRAS) mutations are observed in around 40% of human colorectal adenomas and carcinomas. Previously, we developed and characterized a strain of transgenic mice with inducible intestinal epithelial expression of K‐ras$^{Val12}$ via a Cre/LoxP system. To evaluate the influence of mutant K‐ras on carcinogen‐induced colorectal tumourigenesis, we induced neoplastic alterations in the large intestines...
K‐ras encodes two isoforms, K‐ras 4A and 4B, that are jointly affected by K‐ras activating mutations, which are prevalent in colorectal cancer (CRC). CRC shows alterations in the expressed K‐ras 4A : 4B isoform ratio in favour of K‐ras 4B, in tumours both with and without K‐ras mutations. The present study evaluated whether K‐ras 4A expression can suppress colonic adenoma development in the absence...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.