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In this study, an examination of the potential effect of lipids on the first‐pass metabolism of anethol trithione (ATT) was investigated. ATT is metabolized rapidly and extensively in liver into 4‐hydroxy‐anethole trithione (ATX), which was confirmed using the rat intestinal perfusion with the mesenteric cannulation model. Male Sprague–Dawley rats were orally administered of the lipid‐based formulations...
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