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Since January 1993 we are conducting a randomized phase III study in pts with metastatic colorectal carcinoma comparing 5-FU (425 mg/m 2 )/FA (20mg/m 2 ) days 1–5 as iv bolus therapy given every 4 weeks (arm A) with weekly high-dose 5-FU (2600mg/m 2 ) 24-hour infusion (arm B).So far, 37 pts in each arm are evaluable for response and toxicity. Pts in both arms are comparable...
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