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Bone marrow stroma-derived growth factor (SF20/IL25) regulates proliferation of lymphoid cells. We previously observed the upregulation of SF20/IL25 in alveolar macrophages treated with fine TiO2 particles and in a TiO2 particle-treated animal model. To identify the mechanism behind TiO2 particle-induced expression of SF20/IL25, we examined the dependence of the induction process on reactive oxygen...
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