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Simultaneous precise localization and activity evaluation of a biomolecule in a single living cell is through an enzyme‐specific signal‐amplification process, which involves the localized, site‐specific self‐assembly, and activation of a presignaling molecule. The inactive presignaling tetraphenylethylene (TPE)‐peptide derivative, TPE‐YpYY, is nondetectable and highly biocompatible and these small...
A spatiotemporally‐controllable peptide‐based nanoassembly in a single living cell, for a biological self‐portrait is reported by Xing‐Jie Liang and co‐workers in article number 1601128. The suitability of the synthesized probe is indicated by rapid cell permeation, sitespecific in situ self‐assembly, responsive fluorescence, superior biocompatibility and sensitivity, and robustness, which allows...
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