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A number of liposomal preparations of norfloxacin (NF) containing variable concentrations of phosphatidylcholine (PC) (10.8–16.2mM) have been formulated and an entrapment of NF to the extent of 41.7–56.2% was achieved. The values of apparent first-order rate constants (kobs) for the photodegradation of NF in liposomes (pH7.4) lie in the range of 1.05–2.40×10−3min−1 compared to a value of 8.13×10−3...
The kinetics of photodegradation of norfloxacin (NF) on UV irradiation in aqueous solution (pH 2–12) and in organic solvents has been studied using a validated HPLC method. The apparent first-order rate constants (k obs ) for the reaction in aqueous solution range from 0.28 (pH 2) to 5.19×10 −3 min −1 (pH 10) and in organic solvents from 0.34 (1-butanol) to 0.80×10 −3 ...
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