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Background and Aims
Hepatocellular carcinoma (HCC) is often accompanied by resistance to immunotherapies despite the presence of tumor‐infiltrating lymphocytes. We report that histone deacetylase 6 (HDAC6) represses interleukin‐17 (IL‐17)–producing helper T (TH17) cell pathogenicity and the antitumor immune response, dependent on its deacetylase activity.
Approach and Results
Adoptive transfer...
Liver fibrosis and its endstage, cirrhosis, represent a major public health problem worldwide. Activation of hepatic stellate cells (HSCs) is a central event in hepatic fibrosis. However, the proteins that control HSC activation are incompletely understood. Here we show that (6aS, 10S, 11aR, 11bR, 11cS)‐10‐methylamino‐dodecahydro‐3a, 7a‐diaza‐benzo [de]anthracene‐8‐thione (MASM) exhibits potent inhibitory...
c‐Myc (Myc) plays an important role in normal liver development and tumorigenesis. We show here that Myc is pathologically activated in and essential for promoting human hepatocellular carcinoma (HCC). Myc induces HCC through a novel, microRNA (miRNA)‐mediated feedback loop comprised of miR‐148a‐5p, miR‐363‐3p, and ubiquitin‐specific protease 28 (USP28). Myc directly binds to conserved regions in...
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