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ABSTRACT
BACKGROUND AND PURPOSETo provide guidance regarding the most appropriate voxel‐based morphometry (VBM)‐derived method for assessing hippocampal atrophy in early Alzheimer's disease (AD).
METHODST1‐MRI volume data were collected in 23 patients with amnestic mild cognitive impairment (aMCI) and 18 controls. Three types of data (unmodulated and 2 types of modulated MRI) and 2 extraction methods (with reference to the hippocampal peak of atrophy identified from a preliminary whole‐brain analysis, or using a template region of interest–ROI–approach) were compared to the gold‐standard individual ROI (ROI‐i) method through 2 statistical approaches (ANOVA and Pearson's R)....
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