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Genetic defects in the sodium channel or in the calcium channel have been identified in patients with Brugada syndrome (BS). However, the differences in their genotype-phenotype correlations are still unclear.We evaluated the phenotypic differences and therapeutic effects between the sodium channel and calcium channel abnormalities in in vitro models of BS.We created two models of BS in 18 isolated...
Although radiofrequency catheter ablation (RFCA) has been used to treat patients with Brugada syndrome (BS), it is difficult to eliminate polymorphic ventricular tachycardias (VTs) completely.The purpose of this study was to determine the efficacy of RFCA in eliminating recurrent VTs in an experimental model of BS.We optically mapped electrical activity on the epicardial (n = 9) or transmural (n =...
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