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Polyadenylation occurs at numerous sites within 3′‐untranslated regions (3′‐UTRs) but rarely within coding regions. How does Pol II travel through long coding regions without generating poly(A) sites, yet then permits promiscuous polyadenylation once it reaches the 3′‐UTR? The cleavage/polyadenylation (CpA) machinery preferentially associates with 3′‐UTRs, but it is unknown how its recruitment is...
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