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Angiotensin converting enzyme (ACE) 2 is a key negative regulator of the renin–angiotensin system where it metabolizes angiotensin (Ang) II into Ang 1–7. We hypothesize that Ang II suppresses ACE2 by increasing TNF-α converting enzyme (TACE) activity and ACE2 cleavage. Ang II infusion (1.5mg/kg/day) in wild-type mice for 2weeks resulted in substantial decrease in myocardial ACE2 protein levels and...
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