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Alagille syndrome is a genetic disorder characterized by cholestasis, ocular abnormalities, characteristic facial features, heart defects, and vertebral malformations. Most cases are associated with mutations in JAGGED1 (JAG1), which encodes a Notch ligand, although it is not clear how these contribute to disease development. We aimed to develop a mouse model of Alagille syndrome to elucidate these...
The epithelium of the intestinal tract is the most vigorously self‐renewing tissue of mammals with a turnover rate of 5–7 days. To sustain this, new cells are continuously generated by a population of multipotent intestinal stem cells that give rise to daughter or progenitor cells, which can subsequently differentiate into the different mature cell types. In order to maintain tissue homeostasis, the...
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