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Effects of Zn 2+ on the activity and conformation of cytochorome P450 3A4 (CYP3A4) were investigated. Zn 2+ specifically inhibited the testosterone 6β-hydroxylation activity of CYP3A4 with an IC 50 value of 27μM. Zn 2+ inhibited the CO-binding spectra of CYP3A4 reduced by NADPH-cytochrome P450 reductase (CPR) and NADPH only in the presence of b 5 . Zn 2+...
Hemin, a stable form of heme, is known to have an antimutagenic effect. Inhibitory effects of hemin on the cytochrome P450 (CYP)-catalyzed reactions of human liver microsomes and reconstituted systems containing purified CYP and NADPH-cytochrome P450 reductase (NPR) were seen. Hemin non-specifically inhibited all of the microsomal CYP activities examined. Hemin also inhibited 7-ethoxyresorufin O-deethylation,...
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