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Prion is a host-encoded protein and folds into at least two conformations, physiological PrPC and pathogenic PrPSc. PrPSc mediates the conversion of PrPC into PrPSc. Since prion-binding agents are expected to show inhibitory or stimulating effects on the conversion of prion protein, the binding compounds are promising candidates for the anti-prion disease agents. We established an ELISA assay system...
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