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Two common conjugated linoleic acids (LAs), cis‐9, trans‐11 CLA (c9,t11 CLA) and trans‐10, cis‐12 CLA (t10,c12 CLA), exert various biological activities. However, the effect of CLA on the generation of neurotoxic amyloid‐β (Aβ) protein remains unclear. We found that c9,t11 CLA significantly suppressed the generation of Aβ in mouse neurons. CLA treatment did not affect the level of β‐site APP‐cleaving...