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It is known that CD48 regulates T-cell activation. We evaluated the transcriptional expression of CD48 in CD4 + T cells from 30 SLE patients and 30 healthy controls. CD48 mRNA levels were considerably higher in the patients group: 1.80±1.41 versus 1.10±0.50 (p=0.023). An inverse correlation was obtained with respect to CD48 mRNA levels and age in the control group (r=−0.478, p=0.007). None...
Objectives Xenotropic murine leukemia virus-related virus (XMRV)-specific proviral DNA has been recently detected in peripheral blood mononuclear cells of patients with chronic fatigue syndrome. Since chronic fatigue is commonly reported in patients with systemic lupus erythematosus (SLE) we aimed at testing the presence of this virus in these patients. Methods Ninety-five SLE patients, 45 of whom...
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