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Smad ubiquitination regulatory factor 2 (Smurf2), a ubiquitin ligase for Smads, plays critical roles in the regulation of transforming growth factor-β (TGF-β)-Smad signaling via ubiquitin-dependent degradation of Smad2 and Smad7. We found that TGF-β stimulates Smurf2 expression. TGF-β activated the Smurf2 promoter in a TGF-β responsive cell lines, whereas IL-1α, PDGF and epidermal growth factor did...
Interleukin-6 (IL-6) production is up-regulated by several stimuli through the activation of transcription factors. We have previously demonstrated that CCAAT/enhancer binding protein homologous protein (CHOP) positively regulates IL-6 production at the transcriptional level in the human melanoma cell line A375. In this study, we provide evidence that CHOP up-regulates the IL-6 transcription without...
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