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Background In Alzheimer’s disease (AD), pathological changes may arise up to 20 years before the onset of dementia. This pre-dementia window provides a unique opportunity for secondary prevention. However, exposing non-demented subjects to putative therapies requires reliable biomarkers for subject selection, stratification, and monitoring of treatment. Neuroimaging allows the detection of early pathological...
Positron emission tomography (PET) is a tomographic imaging technique that allows for accurate non-invasive in vivo measurements of regional tissue function in man. It is the most selective and sensitive imaging modality able to measure molecular pathways and interactions in vivo at a picomolar level. PET is an important tool in drug development and can be used in different ways. Firstly, it is possible...
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