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Long‐term ketamine abuse can cause significant lower urinary tract symptoms in humans, termed ketamine‐associated cystitis (KC). Here, we established a model of long‐term (6 months) ketamine administration in wild‐type (C57BL/6) mice. We elucidated the pathological effects of ketamine in the bladder and investigated changes in autophagy‐associated protein expression (i.e., LC3, Beclin‐1, and P62)...