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The mechanisms of carcinogenesis in nervous tissues are not well understood. It is now established that adenosine 3,′,5′-cyclic monophosphate (cAMP)-pathway plays a crucial role in initiating differentiation in transformed and embryonic cells of neuronal and glial origin. Therefore, we propose that defects in the cAMP-pathway may initiate the first phase of carcinogenesis (immortalization). Subsequent...
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