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GluR5-containing kainite receptor (GluR5–KAR) plays an important role in the pathophysiology of nervous system diseases, while S-nitrosylation exerts a variety of effects on biological systems. However, the mechanism of GluR5–KAR S-nitrosylation is still unclear up to now. Here our researches found that GluR5–KAR selective agonist ATPA stimulation activated the nonclassical GluR5–KAR–Gq–PLC–IP ...
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