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Abstract The effect of 5-HT1B receptor stimulation on dopamine-mediated reinforcement in rats was investigated using intravenous self-administration of the selective dopamine uptake inhibitor GBR-12909 on an FR5 schedule of reinforcement. Pretreatment with the 5-HT1A/1B receptor agonist CGS-12066B (110mg/kg, IP) dose-dependently reduced the self-administration of GBR-12909 (83g/injection) by increasing...
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