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SCH 66712 is a potent and selective dopamine D 4 receptor antagonist. An HPLC method was developed for the analysis of SCH 66712 in the plasma of rats, a species used for safety evaluation of this compound. The method involved solid-phase extraction on an ethyl cartridge and HPLC separation on a reversed-phase C 8 column with quantitation using a fluorescence detector. The calibration...
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