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Trebananib, a peptide-Fc fusion protein, inhibits angiogenesis by inhibiting binding of angiopoietin-1/2 to the receptor tyrosine kinase Tie2. This randomised, double-blind, placebo-controlled phase 3 study evaluated whether trebananib plus pegylated liposomal doxorubicin (PLD) improved progression-free survival (PFS) in patients with recurrent epithelial ovarian cancer.Women with recurrent ovarian...
Conatumumab is a fully human monoclonal agonist antibody that binds to death receptor 5 and induces apoptosis in sensitive cells. This study evaluated the safety and efficacy of doxorubicin±conatumumab as first-line systemic therapy for metastatic or locally advanced/unresectable soft-tissue sarcoma.In Phase I, six patients received doxorubicin (75mg/m 2 ) with conatumumab (15mg/kg) every...
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