Search results for: Anthony Cammarato

Items from 1 to 20 out of 40 results

article

The actin ‘A‐triad's’ role in contractile regulation in health and disease

William Schmidt, Anthony Cammarato

The Journal of Physiology > 598 > 14 > 2897 - 2908

Striated muscle contraction is regulated by Ca²⁺‐dependent modulation of myosin cross‐bridge binding to F‐actin by the thin filament troponin (Tn)‐tropomyosin (Tm) complex. In the absence of Ca²⁺, Tn binds to actin and constrains Tm to an azimuthal location where it sterically occludes myosin binding sites along the thin filament surface. This limits force production and promotes muscle relaxation...

article

Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy

Stanley M. Walls, Anthony Cammarato, Dale A. Chatfield, Karen Ocorr, more

Cell Reports > 2018 > 22 > 10 > 2702-2715

Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is unclear. Here, we investigated the association of ceramide metabolism and ceramide-interacting proteins (CIPs) in LCM in the Drosophila heart model. We find that ceramide feeding or ceramide-elevating genetic manipulations...

article

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Meera C. Viswanathan, William Schmidt, Michael J. Rynkiewicz, Karuna Agarwal, more

Cell Reports > 2017 > 20 > 11 > 2612-2625

Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks or exposes myosin binding sites on actin. Findings suggest that electrostatic contacts, particularly those between K326, K328, and R147 on actin and tropomyosin, establish an energetically favorable F-actin-tropomyosin configuration, with tropomyosin positioned in a location that impedes...

article

ACTA1-Related Nemaline Myopathy Mutations Engender a Range of Structural and Functional Phenotypes in Drosophila Indirect Flight Muscles

Aditi Madan, Meera C. Viswanathan, Manuela Lavorato, William Schmidt, more

Biophysical Journal > 2017 > 112 > 3 Supplement 1 > 182a

article

Cardiac-Specific Expression of VCP/TER94 RNAi or Disease Alleles Disrupts Drosophila Heart Structure and Impairs Function

Anna C. Blice-Baum, Meera C. Viswanathan, Tzu-Kang Sang, Anthony Cammarato

Biophysical Journal > 2017 > 112 > 3 Supplement 1 > 559a-560a

article

Acetylation of K326 and K328 on Actin Boosts Contractile Properties of Muscle In Vitro and In Vivo

William Schmidt, Meera C. Viswanathan, D. Brian Foster, Anthony Cammarato

Biophysical Journal > 2017 > 112 > 3 Supplement 1 > 483a

article

Expression of Myosin Storage Myopathy Mutations in Drosophila Disrupts Muscle Function, Myofibrillar Structure and Causes Defects in Thick Filament Assembly

Meera C. Viswanathan, Rick Tham, William A. Kronert, William Schmidt, more

Biophysical Journal > 2017 > 112 > 3 Supplement 1 > 117a

article

A R146N Hypertrophic Cardiomyopathy Myosin Mutation Disrupts Myosin Function, Myofibrillar Structure, and Cardiac Contraction in Drosophila

Adriana S. Trujillo, William A. Kronert, Kaylyn Bell, Meera C. Viswanathan, more

Biophysical Journal > 2017 > 112 > 3 Supplement 1 > 264a

article

The Actc A295S Hypertrophic Cardiomyopathy Mutation Promotes Thin Filament Disinhibition and Enhances Contractile Activity

Meera C. Viswanathan, William Schmidt, Marek Orzechowski, William Lehman, more

Biophysical Journal > 2017 > 112 > 3 Supplement 1 > 559a

article

A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila

Madhulika Achal, Adriana S. Trujillo, Girish C. Melkani, Gerrie P. Farman, more

Journal of Molecular Biology > 2016 > 428 > 11 > 2446-2461

An “invariant proline” separates the myosin S1 head from its S2 tail and is proposed to be critical for orienting S1 during its interaction with actin, a process that leads to muscle contraction. Mutation of the invariant proline to leucine (P838L) caused dominant restrictive cardiomyopathy in a pediatric patient (Karam et al., Congenit. Heart Dis. 3:138–43, 2008). Here, we use Drosophila melanogaster...

article

The Actin F352S Nemaline Myopathy Mutation Disrupts Indirect Flight Muscle Structure and Function in Drosophila

Manuela Lavorato, William Schmidt, Meera C. Viswanathan, Julien Ochala, more

Biophysical Journal > 2016 > 110 > 3 Supplement 1 > 128a

article

Vinculin Remodeling of the Sarcomere Lattice Regulates Contractile Function

Gaurav Kaushik, Jennifer Van Eyk, Anthony Cammarato, Adam Engler

Biophysical Journal > 2016 > 110 > 3 Supplement 1 > 94a

article

Overexpression of Foxo in the Heart Ameliorates Performance Decline through Enhanced UPS Processing in Aging Drosophila

Anna C. Blice-Baum, Gaurav Kaushik, Meera C. Viswanathan, Alexander C. Zambon, more

Biophysical Journal > 2015 > 108 > 2 Supplement 1 > 361a

article

The R146N and R249Q Myosin Mutations Disrupt Motor Function and Myofibrillar Structure and cause Cardiomyopathy in Drosophila

Meera Cozhimuttam Viswanathan, William Kronert, Girish Melkani, Anju Melkani, more

Biophysical Journal > 2015 > 108 > 2 Supplement 1 > 445a

article

Pseudo-Acetylation of Actin Residues K326 and K328 Disrupts Drosophila Flight Performance and Muscle Structure

William M. Schmidt, Meera Cozhimuttam Viswanathan, Anna C. Blice-Baum, D. Brian Foster, more

Biophysical Journal > 2015 > 108 > 2 Supplement 1 > 421a-422a

article

The ACTC A295S Mutation Increases Heart and Skeletal Muscle Contractile Activity in Drosophila Models of Hypertrophic Cardiomyopathy

Meera C. Viswanathan, Bernadette M. Glasheen, Kaylyn Bell, Douglas M. Swank, more

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 774a

article

Cardiac-Specific Overexpression of FOXO Affords Protection Against Age-Associated Decline in Cardiac Performance in the Drosophila Model

Anna Blice-Baum, Guarav Kaushik, Meera C. Viswanathan, Rolf Bodmer, more

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 777a

article

Myosin Storage Myopathy Mutations Disrupt Myofibrillar Assembly/ Stability and Cause Progressive Muscle Degeneration in a Drosophila Model

Meera Cozhimuttam Viswanathan, William A. Kronert, Girish C. Melkani, Anthony Cammarato, more

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 777a

article

Vinculin-Mediated Cytoskeletal Remodeling Modulates Cardiac Morphology and Contractile Function During Ageing

Gaurav Kaushik, Alice Spenlehauer, Ayla Sessions, Danielle Pohl, more

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 778a

article

A Troponin-T Mutation Initiates Cardiac and Skeletal Myopathy due to Impaired Inhibition of Contraction in Drosophila Melanogaster

Meera Cozhimuttam Viswanathan, William Lehman, Anthony Cammarato

Biophysical Journal > 2013 > 104 > 2 Supplement 1 > 311a

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INFONA - science communication portal

Search results for: Anthony Cammarato

The actin ‘A‐triad's’ role in contractile regulation in health and disease

Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

ACTA1-Related Nemaline Myopathy Mutations Engender a Range of Structural and Functional Phenotypes in Drosophila Indirect Flight Muscles

Cardiac-Specific Expression of VCP/TER94 RNAi or Disease Alleles Disrupts Drosophila Heart Structure and Impairs Function

Acetylation of K326 and K328 on Actin Boosts Contractile Properties of Muscle In Vitro and In Vivo

Expression of Myosin Storage Myopathy Mutations in Drosophila Disrupts Muscle Function, Myofibrillar Structure and Causes Defects in Thick Filament Assembly

A R146N Hypertrophic Cardiomyopathy Myosin Mutation Disrupts Myosin Function, Myofibrillar Structure, and Cardiac Contraction in Drosophila

The Actc A295S Hypertrophic Cardiomyopathy Mutation Promotes Thin Filament Disinhibition and Enhances Contractile Activity

A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila

The Actin F352S Nemaline Myopathy Mutation Disrupts Indirect Flight Muscle Structure and Function in Drosophila

Vinculin Remodeling of the Sarcomere Lattice Regulates Contractile Function

Overexpression of Foxo in the Heart Ameliorates Performance Decline through Enhanced UPS Processing in Aging Drosophila

The R146N and R249Q Myosin Mutations Disrupt Motor Function and Myofibrillar Structure and cause Cardiomyopathy in Drosophila

Pseudo-Acetylation of Actin Residues K326 and K328 Disrupts Drosophila Flight Performance and Muscle Structure

The ACTC A295S Mutation Increases Heart and Skeletal Muscle Contractile Activity in Drosophila Models of Hypertrophic Cardiomyopathy

Cardiac-Specific Overexpression of FOXO Affords Protection Against Age-Associated Decline in Cardiac Performance in the Drosophila Model

Myosin Storage Myopathy Mutations Disrupt Myofibrillar Assembly/ Stability and Cause Progressive Muscle Degeneration in a Drosophila Model

Vinculin-Mediated Cytoskeletal Remodeling Modulates Cardiac Morphology and Contractile Function During Ageing

A Troponin-T Mutation Initiates Cardiac and Skeletal Myopathy due to Impaired Inhibition of Contraction in Drosophila Melanogaster

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