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IgE synthesis by human B cells results from allergen-dependent, T H 2-mediated isotype switching. Exposure to a farming environment protects against IgE responses.We reconstructed allergen-dependent switching patterns in vivo to identify the level or levels at which farm exposure acts to protect against atopy.Serum IgG1 to IgG4 and IgE to grass (rPhl p 1 and rPhl p 5), cat (rFel d 1), and...
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