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Cancer chemotherapy typically relies on drug endocytosis and inhibits tumor cell proliferation via intracellular pathways; however, severe side effects may arise. In this study, we performed a first attempt to develop macromolecular‐induced extracellular chemotherapy involving biomineralization by absorbing calcium from the blood through a new type of drug, polysialic acid conjugated with folate (folate‐polySia),...
Ein makromolekularer Wirkstoff , Polysialinsäure konjugiert mit Folat (Folat‐polySia), wurde von Ruikang Tang, Ben Wang und Mitarbeitern in ihrem Forschungsartikel auf S. 6583 als extrazelluläres Chemotherapeutikum gegen maligne Tumorerkrankungen entwickelt. Der neuartige Wirkstoff verbindet sich mit dem Folatrezeptor und induziert über die Aufnahme von Kalzium aus dem Blut selektiv die biogene Mineralbildung...
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