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Abstract. Presenilin-2 (PS2) is one of three genes [amyloid precursor protein (APP), presenilin-1 (PS1) and PS2] shown to cause familial Alzheimers disease (FAD), and is highly homologous to PS1. Currently demonstrated functions of PS2 include interactions with APP and A, and participation in apoptotic pathways. PS2 FAD mutations influence APP processing in a manner predicted to promote amyloid formation...
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