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Hydrophobic ultrasmall nanoparticles synthesized in nonpolar solvents exhibit great potential in biomedical applications. However, a major challenge when applying these nanomaterials in biomedical research is the lack of a versatile strategy to render them water dispersible while preserving the hydrodynamic diameter (HD) to be less than 8 nm for efficient renal clearance. To address this problem,...
A simple, versatile, and inexpensive strategy is developed by H. Zhang, Z. Wang, and co‐workers for transferring small hydrophobic nanoparticles into an aqueous phase using raw tryptone as a phase‐transfer agent. On page 3676, using tryptone‐NaGdF4 nanodots as typical examples, the nanodots are found to have excellent colloidal stability, outstanding MRI‐enhancing performance, efficient renal clearance,...
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