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The TAK kinases belong to the MAPKKK group and have been implicated in a variety of signaling events. Originally described as a TGF-β activated kinase (TAK) it has, however, subsequently been demonstrated to signal through p38, Jun N-terminal kinase (JNK) and Nemo types of MAP kinases, and the NFκB inducing kinase. Despite these multiple proposed functions, the in vivo role of TAK family kinases remains...
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