Search results for: Hitoshi Ikeda

Items from 1 to 20 out of 161 results

article

A nationwide phase II study of delayed local treatment for children with high‐risk neuroblastoma: The Japan Children's Cancer Group Neuroblastoma Committee Trial JN‐H‐11

Akihiro Yoneda, Hiroyuki Shichino, Tomoro Hishiki, Kimikazu Matsumoto, more

Pediatric Blood & Cancer > 71 > 6 > n/a - n/a

Purpose Survival rates of patients with high‐risk neuroblastoma are unacceptable. A time‐intensified treatment strategy with delayed local treatment to control systemic diseases has been developed in Japan. We conducted a nationwide, prospective, single‐arm clinical trial with delayed local treatment. This study evaluated the safety and efficacy of delayed surgery to increase treatment intensity...

article

Downregulation of type III interferons in patients with severe COVID‐19

Yosuke Fukuda, Tetsuya Homma, Hideki Inoue, Chisato Onitsuka, more

Journal of Medical Virology > 93 > 7 > 4559 - 4563

Coronavirus disease 2019 (COVID‐19) is globally rampant, and to curb the growing burden of this disease, in‐depth knowledge about its pathophysiology is needed. This was an observational study conducted at a single center to investigate serum cytokine and chemokine levels of COVID‐19 patients, based on disease severity. We included 72 consecutive COVID‐19 patients admitted to our hospital from March...

article

Identification of novel biomarkers of hepatocellular carcinoma by high‐definition mass spectrometry: Ultrahigh‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging

Koshi Nagai, Baasanjav Uranbileg, Zhen Chen, Amane Fujioka, more

Rapid Communications in Mass Spectrometry > 34 > S1 > n/a - n/a

Rationale Hepatocellular carcinoma (HCC) is a highly malignant disease for which the development of prospective or prognostic biomarkers is urgently required. Although metabolomics is widely used for biomarker discovery, there are some bottlenecks regarding the comprehensiveness of detected features, reproducibility of methods, and identification of metabolites. In addition, information on localization...

article

Results of a prospective clinical trial JN‐L‐10 using image‐defined risk factors to inform surgical decisions for children with low‐risk neuroblastoma disease: A report from the Japan Children's Cancer Group Neuroblastoma Committee

Tomoko Iehara, Akihiro Yoneda, Isao Yokota, Hideto Takahashi, more

Pediatric Blood & Cancer > 66 > 11 > n/a - n/a

Background The present study sought to reduce the incidence of treatment complications of low‐risk neuroblastoma by using image‐defined risk factors (IDRFs) to inform the timing of surgical resection. Procedures Eligible patients included children (<18 years of age) with stage 1 or 2 disease, children (<365 days of age) with stage 3 disease, and infants with stage 4S disease. In IDRF‐negative...

article

Liver stiffness measurements in chronic hepatitis C: Treatment evaluation and risk assessment

Ryo Nakagomi, Ryosuke Tateishi, Ryota Masuzaki, Yoko Soroida, more

Journal of Gastroenterology and Hepatology > 34 > 5 > 921 - 928

Background and Aim Liver stiffness (LS), measured by transient elastography, has been validated as a non‐invasive surrogate for liver fibrosis. Methods We investigated the long‐term predictive ability of LS for hepatocellular carcinoma (HCC) development and overall survival in 1146 patients with chronic hepatitis C by using LS value at enrollment. We also investigated chronological changes in LS...

article

Identification of liver fibrosis using the hepatic vein waveform in patients with Fontan circulation

Takuma Nakatsuka, Yoko Soroida, Hayato Nakagawa, Takahiro Shindo, more

Hepatology Research > 49 > 3 > 304 - 313

Aim Liver fibrosis caused by congestive hepatopathy has emerged as an important complication after Fontan procedure. We evaluated the utility of the hepatic vein (HV) waveform using Doppler ultrasound for identification of liver fibrosis in Fontan patients. Methods We investigated the HV waveforms in 41 Fontan patients and assessed correlations with clinical parameters, liver fibrosis markers,...

article

Acquired isolated hypoganglionosis as a distinct entity: results from a nationwide survey

Satoshi Obata, Koichiro Yoshimaru, Kosuke Kirino, Tomoko Izaki, more

Pediatric Surgery International > 2019 > 35 > 2 > 215-220

Purpose Acquired isolated hypoganglionosis (A-IH) is a late-onset intestinal pseudo-obstruction disorder and shows different pathophysiological findings from congenital isolated hypoganglionosis (C-IH). In this study, we retrospectively examined five cases of A-IH and investigated the features of A-IH. Methods Five cases of A-IH were extracted from a nationwide retrospective cohort study in 10 years,...

article

Surgical exploration for impalpable testis: Which should be first, inguinal exploration or laparoscopic abdominal exploration?

Akihiro Igarashi, Kenta Kikuchi, Kenjiro Ogushi, Mariko Hasegawa, more

Journal of Pediatric Surgery > 2018 > 53 > 9 > 1766-1769

To discuss an optimal surgical approach for impalpable testis in children, our own treatment results and those reported in the literature were reviewed.Seventy-two impalpable testes were diagnosed in 68 patients: unilateral in 64 patients and bilateral in 4 patients. All patients underwent surgical exploration at the ages of 6 to 140months (median, 15months). The inguinal canal was initially explored,...

article

Hepatic IRS1 and ß-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients

Kenichiro Enooku, Mayuko Kondo, Naoto Fujiwara, Takayoshi Sasako, more

Journal of Gastroenterology > 2018 > 53 > 12 > 1261-1275

Background Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes. Our aim was to investigate the relationship between NAFLD and impaired glucose metabolism in terms of insulin receptor substrate 1 and 2 (IRS1 and IRS2) expression in the liver. Methods Liver biopsy was performed at the University of Tokyo Hospital between November 2011 and March 2016 on 146 patients with NAFLD...

article

Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a report from the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG)

Tomoro Hishiki, Kimikazu Matsumoto, Miki Ohira, Takehiko Kamijo, more

International Journal of Clinical Oncology > 2018 > 23 > 5 > 965-973

Background The Japanese Children’s Cancer Group (JCCG) Neuroblastoma Committee (JNBSG) conducted a phase II clinical trial for high-risk neuroblastoma treatment. We report the result of the protocol treatment and associated genomic aberration studies. Methods JN-H-07 was a single-arm, late phase II trial for high-risk neuroblastoma treatment with open enrollment from June 2007 to February 2009....

article

Association between serum autotaxin or phosphatidylserine‐specific phospholipase A1 levels and melanoma

Makoto Kurano, Tomomitsu Miyagaki, Takuya Miyagawa, Koji Igarashi, more

The Journal of Dermatology > 45 > 5 > 571 - 579

Autotaxin (ATX), a producing enzyme for lysophosphatidic acids, was first identified from the medium of a melanoma cell line and has been considered to be one of the candidate targets to treat melanoma; however, the association between serum ATX and melanoma in human subjects has not been elucidated. Along with ATX, phosphatidylserine‐specific phospholipase A1 (PS‐PLA₁) is a producing enzyme for lysophosphatidylserine,...

article

Ictal single photon emission computed tomographic study of myoclonic absence seizures

Hiroko Ikeda, Katsumi Imai, Hitoshi Ikeda, Kazumi Matsuda, more

Brain and Development > 2018 > 40 > 2 > 126-129

Epilepsy with myoclonic absences (EMAs) is a rare epileptic disorder characterized by a predominant type of seizures, myoclonic absences (MAs). The pathophysiology of MAs in patients with EMAs remains unknown. Here, we report the first characterization of the ictal phase of MAs by single photon emission computed tomography (SPECT).We evaluated 1 male (Patient 1) and 1 female (Patient 2) patient with...

article

Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination

Yukitoshi Takahashi, Takashi Matsudaira, Hitoshi Nakano, Hirosato Nasu, more

Journal of Neuroimmunology > 2016 > 298 > C > 71-78

In 32 patients with prolonged central nervous system symptoms after human papillomavirus (HPV) vaccination, we measured conventional and immunological markers in cerebrospinal fluid (CSF) and compared with the levels in disease controls. Our studies revealed significantly decreased chloride and neuron-specific enolase (NSE) levels in CSF of patients with CNS symptoms after HPV vaccination compared...

chapter

Size-Independent Image Segmentation by Hierarchical Clustering and Its Application for Face Detection

Motofumi Fukui, Noriji Kato, Hitoshi Ikeda, Hirotsugu Kashimura

Lecture Notes in Computer Science > Neural Information Processing > Image Processing > 686-693

In this paper, we introduce a technique to detect a target object quickly. Our idea is based on onservation on the clusters into which an image is divided by hierarchical k-means clustering with space feature and color feature. This clustering method has the advantage of extracting the region of an object with some varied size. We insist that our idea should lead to detect a target object quickly,...

chapter

Visual Trigger Templates for Knowledge-Based Indexing

Alejandro Jaimes, Qinhui Wang, Noriji Kato, Hitoshi Ikeda, more

Lecture Notes in Computer Science > Advances in Multimedia Information Processing - PCM 2004 > Content-Based Image Retrieval > 154-161

We present an application to create binary Visual Trigger Templates (VTT) for automatic video indexing. Our approach is based on the observation that videos captured with fixed cameras have specific structures that depend on world constraints. Our system allows a user to graphically represent such constraints to automatically recognize simple actions or events. VTTs are constructed by manually drawing...

article

Epithelial–myoepithelial carcinoma of a minor salivary gland in the buccal mucosa

Tsukasa Tsuji, Hideaki Kitada, Sinnosuke Abe, Hitoshi Ikeda, more

Oral Radiology > 2016 > 32 > 2 > 130-135

Epithelial–myoepithelial carcinoma (EMC) is a rare tumor constituting less than 1 % of all salivary gland tumors. This neoplasm most often involves the parotid glands, with less frequent involvement of the submandibular or minor salivary glands. This case report describes EMC arising from a minor salivary gland in the buccal mucosa. A 71-year-old Japanese man with a painless submucosal mass in the...

article

An unusual case of uterine cotyledonoid dissecting leiomyoma with adenomyosis

Ai Shimizu, Hoshihito Tanaka, Sari Iwasaki, Yukio Wakui, more

Diagnostic Pathology > 2016 > 11 > 1 > 1-7

Background Cotyledonoid dissecting leiomyoma is a rare variant of uterine smooth muscle tumor with an unusual growth pattern that shows intramural dissection within uterine myometrium and often a placenta-like appearance in its extrauterine components. Case presentation We present a unique case of cotyledonoid dissecting leiomyoma with adenomyosis. A 40-year-old Japanese female presented with prolonged...

article

Resveratrol exerts a biphasic effect on apolipoprotein M

Makoto Kurano, Masumi Hara, Takahiro Nojiri, Hitoshi Ikeda, more

British Journal of Pharmacology > 173 > 1 > 222 - 233

Background and PurposeResveratrol exerts a range of beneficial actions in several areas of pathophysiology, including vascular biology. Here, we have investigated the effects of resveratrol on apolipoprotein M (apoM), a carrier and modulator of sphingosine 1‐phosphate (S1P), a vasoactive lipid mediator. Experimental ApproachWe used a hepatoma cell line (HepG2), human primary hepatocytes and C57BL/6...

article

Trends in incidence of childhood malignant solid tumors in Japan: Estimation based on hospital-based registration

Hitoshi Ikeda, Yosikazu Nakamura

Journal of Pediatric Surgery > 2015 > 50 > 9 > 1506-1512

In Japan, an increase in hepatoblastoma with low birth weight has become evident since the 1990s, and there is concern about a possible increase in unfavorable neuroblastomas after the cessation of mass screening in 2004.The trends in incidence of malignant solid tumors in children younger than 15years of age were inferred by evaluating registration incidence in the registry of the Japanese Society...

article

Decreased expression of thymus‐specific proteasome subunit β5t in Down syndrome patients

Utano Tomaru, Takahiro Tsuji, Shizuka Kiuchi, Akihiro Ishizu, more

Histopathology > 67 > 2 > 235 - 244

AimsThe majority of patients with Down syndrome (DS), trisomy 21, have morphologically abnormal thymuses and present with intrinsic immunological abnormalities affecting mainly the cellular immune response. The aim of this study was to examine whether the expression of functionally important molecules is altered in thymic stromal cells in patients with DS. Methods and resultsWe analysed thymic tissues...

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INFONA - science communication portal

Search results for: Hitoshi Ikeda

A nationwide phase II study of delayed local treatment for children with high‐risk neuroblastoma: The Japan Children's Cancer Group Neuroblastoma Committee Trial JN‐H‐11

Downregulation of type III interferons in patients with severe COVID‐19

Identification of novel biomarkers of hepatocellular carcinoma by high‐definition mass spectrometry: Ultrahigh‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging

Results of a prospective clinical trial JN‐L‐10 using image‐defined risk factors to inform surgical decisions for children with low‐risk neuroblastoma disease: A report from the Japan Children's Cancer Group Neuroblastoma Committee

Liver stiffness measurements in chronic hepatitis C: Treatment evaluation and risk assessment

Identification of liver fibrosis using the hepatic vein waveform in patients with Fontan circulation

Acquired isolated hypoganglionosis as a distinct entity: results from a nationwide survey

Surgical exploration for impalpable testis: Which should be first, inguinal exploration or laparoscopic abdominal exploration?

Hepatic IRS1 and ß-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients

Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a report from the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG)

Association between serum autotaxin or phosphatidylserine‐specific phospholipase A1 levels and melanoma

Ictal single photon emission computed tomographic study of myoclonic absence seizures

Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination

Size-Independent Image Segmentation by Hierarchical Clustering and Its Application for Face Detection

Visual Trigger Templates for Knowledge-Based Indexing

Epithelial–myoepithelial carcinoma of a minor salivary gland in the buccal mucosa

An unusual case of uterine cotyledonoid dissecting leiomyoma with adenomyosis

Resveratrol exerts a biphasic effect on apolipoprotein M

Trends in incidence of childhood malignant solid tumors in Japan: Estimation based on hospital-based registration

Decreased expression of thymus‐specific proteasome subunit β5t in Down syndrome patients

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