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Lower global cognitive function scores are a common symptom of autism spectrum disorders (ASDs). This study investigates the effects of melatonin on hippocampal serine/threonine kinase signaling in an experimental ASD model. We found that chronic melatonin (1.0 or 5.0 mg/kg/day, 28 days) treatment significantly rescued valproic acid (VPA, 600 mg/kg)‐induced decreases in CaMKII (Thr286), NMDAR1 (Ser896),...
BackgroundDefining the impact of diabetes and related risk factors on brain cognitive function is critically important for patients with diabetes.
AimsTo investigate the alterations in hippocampal serine/threonine kinases signaling in the early phase of type 1 and type 2 diabetic rats.
MethodsEarly experimental diabetes mellitus was induced in rats with streptozotocin or streptozotocin/high fat...
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