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Although phosphatidylinositol 4,5-bisphosphate (PIP 2 ) regulates syndecan-4 function, the potential influence of syndecan-4 on PIP 2 remains unknown. GFP containing PIP 2 -binding-PH domain of phospholipase Cδ (GFP-PHδ) was used to monitor PIP 2 . Syndecan-4 overexpression in COS-7 cells enhanced membrane translocation of GFP-PHδ, while the opposite was observed when...
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