Search results for: Markus Himmelsbach

Items from 1 to 20 out of 47 results

article

A fast‐screening approach for the tentative identification of drug‐related metabolites from three non‐steroidal anti‐inflammatory drugs in hydroponically grown edible plants by HPLC‐drift‐tube‐ion‐mobility quadrupole time‐of‐flight mass spectrometry

Franz Mlynek, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl

The (tentative) identification of unknown drug‐related phase II metabolites in plants upon drug uptake remains a challenging task despite improved analytical instrument performance. To broaden the knowledge of possible drug metabolization, a fast‐screening approach for the tentative identification of drug‐related phase II metabolites is presented in this work. Therefore, an in silico database for...

article

Analysis of polycyclic aromatic hydrocarbons migrating from polystyrene/divinylbenzene-based food contact materials

Andrea Schweighuber, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl

Monatshefte für Chemie - Chemical Monthly > 2019 > 150 > 5 > 901-906

Single-use utensils made from polystyrene (PS), coming into contact with food or beverages during consumption or storage were analyzed with respect to the presence of polycyclic aromatic hydrocarbons (PAHs). Using the developed sample preparation procedure and high-performance liquid chromatography with fluorescence detection allowed the analysis of 14 PS-based items, thereby detecting several PAHs...

article

In Vitro and In Vivo Inhibition of Intestinal Glucose Transport by Guava (Psidium Guajava) Extracts

Ulrike Müller, Flora Stübl, Bettina Schwarzinger, Georg Sandner, more

Molecular Nutrition & Food Research > 62 > 11 > n/a - n/a

Scope Known pharmacological activities of guava (Psidium guajava) include modulation of blood glucose levels. However, mechanistic details remain unclear in many cases. Methods and results This study investigated the effects of different guava leaf and fruit extracts on intestinal glucose transport in vitro and on postprandial glucose levels in vivo. Substantial dose‐ and time‐dependent glucose...

article

Front cover: In Vitro and In Vivo Inhibition of Intestinal Glucose Transport by Guava (Psidium Guajava) Extracts

Ulrike Müller, Flora Stübl, Bettina Schwarzinger, Georg Sandner, more

Molecular Nutrition & Food Research > 62 > 11 > n/a - n/a

Mol. Nutr. Food Res. 2018, 62, 1701012 DOI: 10.1002/mnfr.201701012 Phytochemicals can directly affect intestinal glucose uptake by competitive inhibition of sugar transporters. Anti‐hyperglycemic properties have been so far reported for guava leaves, but there is little understanding of guava fruit extracts in this context. Therefore, the effects of different guava leaf and fruit extracts in vitro...

article

Hydrothermal carbonization as an all-inclusive process for food-waste conversion

Simon B. Tradler, Siegfried Mayr, Markus Himmelsbach, Reinhold Priewasser, more

Bioresource Technology Reports > 2018 > 2 > C > 77-83

Food waste is highly energetic biomass but its recycling and disposal process is costly and time-intensive, and the wet, inhomogeneous waste is unwelcome in biomass plants. Searching for an alternative processing pathway, we studied the feasibility of a decentralized, small-scale hydrothermal carbonization plant. Restaurant food waste was converted at 200 °C for 6 h into high-quality hydrochar that...

article

Insights into the uptake, metabolization, and translocation of four non‐steroidal anti‐inflammatory drugs in cress (Lepidium sativum) by HPLC‐MS²

Lisa Emhofer, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl

ELECTROPHORESIS > 39 > 9-10 > 1294 - 1300

The metabolization of four non‐steroidal anti‐inflammatory drugs by cress (Lepidium sativum) was investigated using a HPLC‐MS² method. Cress was grown hydroponically in water containing 0.1 mg/L of each drug for investigations on the kinetics of drug uptake and metabolization over a growing period of 12 days. It could be shown that the parent drugs are metabolized and the abundance of both the parent...

article

Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress (Lepidium sativum) model

Bernd Reichl, Markus Himmelsbach, Lisa Emhofer, Christian W. Klampfl, more

ELECTROPHORESIS > 39 > 9-10 > 1301 - 1308

Environmental contamination with pharmaceuticals has received growing attention in recent years. Several studies describe the presence of traces of drugs in water bodies and soils and their impacts on nontarget organisms including plants. Due to these facts investigations of the uptake and metabolism of pharmaceuticals in organisms is an emerging research area. The present study demonstrates the analysis...

article

Asymmetric Synthesis of 2,3‐Dihydrobenzofurans by a [4+1] Annulation Between Ammonium Ylides and In Situ Generated o‐Quinone Methides

Nicole Meisinger, Lukas Roiser, Uwe Monkowius, Markus Himmelsbach, more

Chemistry – A European Journal > 23 > 21 > 5137 - 5142

A highly enantio‐ and diastereoselective [4+1] annulation between in situ generated ammonium ylides and o‐quinone methides for the synthesis of a variety of 2,3‐dihydrobenzofurans has been developed. The key factors controlling the reactivity and stereoselectivity were systematically investigated by experimental and computational means and the energy profiles obtained provide a deeper insight into...

article

High-performance liquid chromatography – mass spectrometry analysis of the parent drugs and their metabolites in extracts from cress (Lepidium sativum) grown hydroponically in water containing four non-steroidal anti-inflammatory drugs

Lisa Emhofer, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl

Journal of Chromatography A > 2017 > 1491 > C > 137-144

In this paper the metabolism of four non-steroidal anti-inflammatory drugs, (ketoprofen, mefenamic acid, naproxen, and diclofenac) by cress (Lepidium sativum) is described. Cress was cultivated hydroponically in water spiked with the parent drugs at levels ranging from 0.01mgL⁻¹ to 1mgL⁻¹. Employing an approach based on the analysis of the plant extracts by HPLC coupled either with quadrupole-time-of-flight...

article

Trace level determination of Δ9‐tetrahydrocannabinol in a perfume using liquid chromatography high resolution tandem mass spectrometry and gas chromatography mass spectrometry

Bernhard Thalhamer, Markus Himmelsbach, Wolfgang Buchberger

Flavour and Fragrance Journal > 32 > 1 > 46 - 53

Δ9‐tetrahydrocannabinol (Δ9‐THC), which is the primary psychoactive ingredient in marijuana, was identified at trace levels in a perfume whose name/brand and its scent aim to arouse associations with marijuana/hashish. The presence of Δ9‐THC was unambiguously confirmed by high performance liquid chromatography (HPLC) coupled with Orbitrap high resolution mass spectrometric detection. The relevant...

article

Synthesis and characterization of dinuclear silver(I) complexes with exchangeable nitrile ligands

Elnaz Hobbollahi, Markus Himmelsbach, Manuela List, Uwe Monkowius

Inorganic Chemistry Communications > 2016 > 71 > C > 105-108

We have prepared three silver(I) complexes of the type [Ag₂(P∩N)₃(NCR)](BF₄)₂ with (R=Me, Et, Ph). The crystal structures of the complexes were determined. The nitrile ligands can be easily exchanged by re-crystallisation in the respective nitrile. The luminescence properties were also investigated.

article

Advances in the determination of hindered amine light stabilizers – A review

Christian W. Klampfl, Markus Himmelsbach

Analytica Chimica Acta > 2016 > 933 > C > 10-22

Within this paper we discuss analytical strategies for the characterization and quantitation of hindered amine light stabilizers (HALS) an important sub-group of polymer additives. For the determination of monomeric HALS a range of mature and reliable techniques exists, allowing their determination in polymer extracts. If qualitative or semi-quantitative information suffices, certain techniques are...

article

Investigation of photochemical reaction products of glucose formed during direct UV detection in CE

Thomas Schmid, Markus Himmelsbach, Wolfgang W. Buchberger

ELECTROPHORESIS > 37 > 7-8 > 947 - 953

In CE, saccharides are accessible to direct UV detection due to a photochemical reaction in the detection window of the separation capillary resulting in the formation of UV absorbing substances. Employing a CE method that allows long in‐capillary irradiation with subsequent UV and MS detection, the present study could identify several reaction products of glucose. Among these were UV absorbing substances...

article

Separation and characterization of oligomeric hindered amine light stabilizers using high‐performance liquid chromatography with UV and quadrupole time‐of‐flight mass spectrometric detection

Ingrid Hintersteiner, Michael Reisinger, Markus Himmelsbach, Wolfgang Buchberger

Journal of Separation Science > 39 > 6 > 1056 - 1066

Hindered amine light stabilizers are an important class of stabilizers that protect synthetic polymers from degradation and thus from changing mechanical and optical properties. The current study presents an HPLC method capable of separating oligomeric hindered amine light stabilizers on a commercially available stationary phase, employing an MS‐compatible novel mobile phase. Based on the exact masses...

chapter

Analysis of Simple Carbohydrates by Capillary Electrophoresis and Capillary Electrophoresis–Mass Spectrometry

Christian W. Klampfl, Markus Himmelsbach, Wolfgang Buchberger

Capillary Electrophoresis of Carbohydrates > 1-21

An overview of the application of capillary electrophoresis and capillary electrophoresis–mass spectrometry in the analysis of simple carbohydrates without any previous derivatization step is given. Besides electrolyte systems for carbohydrate separation, detection techniques employed in capillary electrophoresis, such as spectrophotometric detection, electrochemical detection, and mass spectrometric...

article

Asymmetric α-chlorination of β-ketoesters using bifunctional ammonium salt catalysis

Johanna Novacek, Uwe Monkowius, Markus Himmelsbach, Mario Waser

Monatshefte für Chemie - Chemical Monthly > 2016 > 147 > 3 > 533-538

Chiral urea-quaternary ammonium salt hybrid organocatalysts were tested for their capability to control asymmetric α-chlorination reactions of β-ketoesters. After a careful screening we identified a structurally simple catalyst derivative that allowed us to obtain enantiomeric ratios up to 90:10 under operationally simple conditions using just 1 mol% of the catalyst. Graphical abstract

article

Analysis of saccharides in beverages by HPLC with direct UV detection

Thomas Schmid, Benedikt Baumann, Markus Himmelsbach, Christian W. Klampfl, more

Analytical and Bioanalytical Chemistry > 2016 > 408 > 7 > 1871-1878

The present study demonstrates the suitability of direct UV detection for saccharide analysis in HPLC. Under highly alkaline conditions, the non-UV absorbing saccharides are converted by a photo-initiated chemical reaction in the detection cell into malonenolate, which can be detected at 266 nm. A straightforward method for such direct UV detection of saccharides after their separation by anion-exchange...

article

Direct ionization methods in mass spectrometry: An overview

Christian W. Klampfl, Markus Himmelsbach

Analytica Chimica Acta > 2015 > 890 > C > 44-59

Within this paper a sub-group of ambient ionization mass spectrometry namely direct ionization mass spectrometry techniques are reviewed. They are characterized by the generation of an electrospray directly from the sample investigated. Prominent representatives include paper spray mass spectrometry, tissue spray mass spectrometry, probe electrospray ionization or thin-layer chromatography mass spectrometry...

article

Investigation of photochemical reactions of saccharides during direct ultraviolet absorbance detection in capillary electrophoresis

Thomas Schmid, Markus Himmelsbach, James D. Oliver, Marianne Gaborieau, more

Journal of Chromatography A > 2015 > 1388 > Complete > 259-266

Direct UV detection of saccharides in capillary electrophoresis is possible due to a base-catalyzed conversion into UV absorbing substances initiated by the light of the UV detector lamp. In the present study the compounds formed during this reaction were investigated with capillary electrophoresis using an additional UV lamp for online irradiation at a certain distance before the detector resulting...

article

Identification and semi-quantitative determination of anti-oxidants in lubricants employing thin-layer chromatography-spray mass spectrometry

Georg Kreisberger, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl

Journal of Chromatography A > 2015 > 1383 > Complete > 169-174

A quick and simple method for identification and semi-quantitative determination of nine antioxidants commonly used in lubricants is presented. A dual step thin-layer chromatography (TLC) separation, removes in a first step the oil matrix whereas in a second step the antioxidants are separated. Cutting the spots out of the TLC-plate in the form of triangles allows direct-spray mass spectrometric (MS)...

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Keywords

MASS SPECTROMETRY (9)
LIQUID CHROMATOGRAPHY (7)
CAPILLARY ELECTROPHORESIS (4)
ENVIRONMENTAL ANALYSIS (4)
ATMOSPHERIC PRESSURE PHOTOIONIZATION (3)
CE (3)
HINDERED AMINE LIGHT STABILIZERS (3)
MS (3)
PLANT METABOLISM (3)
XENOBIOTICS (3)
ANTIOXIDANTS (2)
CAPILLARY ZONE ELECTROPHORESIS (2)
CZE (2)
DIRECT UV DETECTION (2)
HIGH RESOLUTION MASS SPECTROMETRY (2)
HPLC (2)
MASS SPECTROMETRIC DETECTION (2)
ORGANOCATALYSIS (2)
POLYMER ANALYSIS (2)
POLYMER PRODUCT ANALYSIS (2)
SACCHARIDE (2)
UV‐STABILIZATION (2)
CO 2 REDUCTION (1)
AMBIENT IONIZATION (1)
AMBIENT IONIZATION MASS SPECTROMETRY (1)
ANION-EXCHANGE CHROMATOGRAPHY (1)
ANNULATION (1)
ANTIOXIDANT CAPACITY (1)
APPLE JUICE (1)
ARGENTOPHILICITY (1)
ASYMMETRIC SYNTHESIS (1)
ATMOSPHERIC PRESSURE CHEMICAL IONIZATION (1)
BEER ANALYSIS (1)
BIOCIDAL OLIGOMERIC GUANIDINES (1)
BISMUTH COMPLEXES (1)
CARBOHYDRATES (1)
CATALYSIS (1)
CE‐MS (1)
CHARACTERIZATION (1)
CHIRAL AUXILIARIES (1)
CHROMATOGRAPHY (1)
CINCHONA ALKALOIDS (1)
CLENBUTEROL (1)
COMPOSITION ANALYSIS (1)
CORROLES (1)
CRYSTAL STRUCTURE (1)
CYCLIZATION (1)
CZE‐MS (1)
DENSITY FUNCTIONAL CALCULATIONS (1)
DFT CALCULATIONS (1)
DIRECT ELECTROSPRAY PROBE (1)
DIRECT IONIZATION MASS SPECTROMETRY (1)
DISPERSIVE LIQUID–LIQUID MICROEXTRACTION (DLLME) (1)
DRIFT‐TUBE ION MOBILITY‐MASS SPECTROMETRY (1)
ELECTROCHEMICAL DETECTION (1)
ELECTROCHEMISTRY (1)
ELECTRONIC TRANSITIONS (1)
ELECTROSPRAY IONIZATION MASS SPECTROMETRY (1)
ENERGY (1)
FAST‐SCREENING (1)
FERMENTATION (1)
FOOD ANALYSIS (1)
FOOD SIMULANTS (1)
FOOD WASTE (1)
FTIR ABSORPTION MEASUREMENTS (1)
GEL-PERMEATION CHROMATOGRAPHY (1)
GLUCOSE (1)
GLUT2 (1)
GUAVA EXTRACT (1)
H-BONDING ACTIVATION (1)
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY‐MASS SPECTROMETRY (1)
HIGH-RESOLUTION MASS SPECTROMETRY (1)
HINDERED AMINE LIGHT STABILIZER (1)
HYDROTHERMAL CARBONIZATION (1)
INTESTINAL GLUCOSE TRANSPORT (1)
ION MOBILITY MASS SPECTROMETRY (1)
ION PAIRING (1)
ION-TRAP MASS SPECTROMETRY (1)
KEY WORDS: TETRACYCLINE ANTIBIOTICS; OXYTETRACYCLINE; WATER ANALYSIS; AQUACULTURE; HPLC; ELISA. (1)
LEAF SPRAY (1)
LUBRICANTS (1)
LUMINESCENCE (1)
LYSERGIC ACID (1)
MADHUCA LONGIFOLIA (L.) (1)
MAHUA SEED CAKE (1)
MALONDIALDEHYDE (1)
MELAMINE (1)
MELAMINE IMPURITIES (1)
MELAMINE–FORMALDEHYDE RESINS (1)
METHYLATED MELAMINES (1)
MICROBEADS (1)
MICROEMULSION ELECTROKINETIC CHROMATOGRAPHY (1)
MICROPLASTICS (1)
MIGRATION STUDIES (1)
MOLECULAR MODELING (1)
MONOSACCHARIDES (1)
NON-INTENTIONALLY ADDED SUBSTANCES (1)
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (1)
NON‐AQUEOUS CAPILLARY ELECTROPHORESIS‐MASS SPECTROMETRY (1)
NON‐AQUEOUS CARRIER ELECTROLYTE (1)
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ELECTROPHORESIS (11)
Journal of Chromatography A (7)
Analytica Chimica Acta (3)
Analytical and Bioanalytical Chemistry (3)
Monatshefte für Chemie - Chemical Monthly (3)
Molecular Nutrition & Food Research (2)
Polymer Degradation and Stability (2)
Analytical Chemistry (1)
Biomedical Chromatography (1)
Bioresource Technology Reports (1)
Chemistry – A European Journal (1)
Electrocatalysis (1)
Environmental Science & Technology (1)
Flavour and Fragrance Journal (1)
Inorganic Chemistry Communications (1)
Journal of Chromatography B (1)
Journal of Photochemistry & Photobiology, A: Chemistry (1)
Journal of Separation Science (1)
Microchimica Acta (1)
Nutrition Journal (1)
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INFONA - science communication portal

Search results for: Markus Himmelsbach

A fast‐screening approach for the tentative identification of drug‐related metabolites from three non‐steroidal anti‐inflammatory drugs in hydroponically grown edible plants by HPLC‐drift‐tube‐ion‐mobility quadrupole time‐of‐flight mass spectrometry

Analysis of polycyclic aromatic hydrocarbons migrating from polystyrene/divinylbenzene-based food contact materials

In Vitro and In Vivo Inhibition of Intestinal Glucose Transport by Guava (Psidium Guajava) Extracts

Front cover: In Vitro and In Vivo Inhibition of Intestinal Glucose Transport by Guava (Psidium Guajava) Extracts

Hydrothermal carbonization as an all-inclusive process for food-waste conversion

Insights into the uptake, metabolization, and translocation of four non‐steroidal anti‐inflammatory drugs in cress (Lepidium sativum) by HPLC‐MS²

Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress (Lepidium sativum) model

Asymmetric Synthesis of 2,3‐Dihydrobenzofurans by a [4+1] Annulation Between Ammonium Ylides and In Situ Generated o‐Quinone Methides

High-performance liquid chromatography – mass spectrometry analysis of the parent drugs and their metabolites in extracts from cress (Lepidium sativum) grown hydroponically in water containing four non-steroidal anti-inflammatory drugs

Trace level determination of Δ9‐tetrahydrocannabinol in a perfume using liquid chromatography high resolution tandem mass spectrometry and gas chromatography mass spectrometry

Synthesis and characterization of dinuclear silver(I) complexes with exchangeable nitrile ligands

Advances in the determination of hindered amine light stabilizers – A review

Investigation of photochemical reaction products of glucose formed during direct UV detection in CE

Separation and characterization of oligomeric hindered amine light stabilizers using high‐performance liquid chromatography with UV and quadrupole time‐of‐flight mass spectrometric detection

Analysis of Simple Carbohydrates by Capillary Electrophoresis and Capillary Electrophoresis–Mass Spectrometry

Asymmetric α-chlorination of β-ketoesters using bifunctional ammonium salt catalysis

Analysis of saccharides in beverages by HPLC with direct UV detection

Direct ionization methods in mass spectrometry: An overview

Investigation of photochemical reactions of saccharides during direct ultraviolet absorbance detection in capillary electrophoresis

Identification and semi-quantitative determination of anti-oxidants in lubricants employing thin-layer chromatography-spray mass spectrometry

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