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Die Bildung von Fibrillen aus Insulin und β‐Amyloid wird von Cucurbit[7]uril (CB[7]) über Wirt‐Gast‐Wechselwirkungen verhindert. In ihrer Zuschrift auf S. 7591 ff. demonstrieren K. Kim, H. I. Kim und Mitarbeiter, dass CB[7] hoch affin an Phenylalaninreste bindet, die entscheidend für die hydrophoben Wechselwirkungen während der Amyloidfibrillenbildung sind. Diese supramolekulare Strategie könnte zur...
Amyloid fibrils are insoluble protein aggregates comprised of highly ordered β‐sheet structures and they are involved in the pathology of amyloidoses, such as Alzheimer’s disease. A supramolecular strategy is presented for inhibiting amyloid fibrillation by using cucurbit[7]uril (CB[7]). CB[7] prevents the fibrillation of insulin and β‐amyloid by capturing phenylalanine (Phe) residues, which are crucial...
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