The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
DNA topoisomerase II beta (TOP2B) has a role in transcriptional regulation. Here, to further investigate transcriptional regulation by TOP2B, we used RNA‐sequencing and real‐time PCR to analyse the differential gene expression profiles of wild‐type and two independent TOP2B‐null pre‐B Nalm‐6 cell lines, one generated by targeted insertion and the other using CRISPR‐Cas9 gene editing. We identified...
Rearrangements involving the RUNX1 gene account for approximately 15% of balanced translocations in therapy‐related acute myeloid leukemia (t‐AML) patients and are one of the most common genetic abnormalities observed in t‐AML. Drugs targeting the topoisomerase II (TOP2) enzyme are implicated in t‐AML; however, the mechanism is not well understood and to date a single RUNX1‐RUNX1T1 t‐AML breakpoint...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.