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BackgroundIn experimental models, bone marrow‐derived mesenchymal stem cells (BM‐MSCs) have the capacity to differentiate into hepatocytes and exhibit antifibrotic effects. However, there have been no studies in humans with alcoholic cirrhosis.
AimThe aim of this study was to elucidate the antifibrotic effect of BM‐MSCs in patients with alcoholic cirrhosis, as a phase II clinical trial.
MethodsTwelve...
BackgroundRecent studies have shown that the renin‐angiotensin system is implicated in hepatic fibrogenesis in vitro and in vivo. However, no study was done in humans with alcoholic liver disease.
AimTo investigate the antifibrotic effect of angiotensin II type 1 receptor (AT1‐R) blocking agents (ARB) in patients with alcoholic liver disease.
MethodsThe primary outcome was improvement in patients'...
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